Paul Reier Paul Reier studies the cell biology of neurons and glia in the developing and injured peripheral and central nervous systems Professor of Neuroscience Investigator, McKnight Brain Institute Training Ph.D. Anatomy, Case-Western Reserve University, Cincinnati, OH Contact phone: 352.392.5644 office: MBI L1-100K lab: MBI L1-135 email:reier@mbi.ufl.edu Our overall goal is to find approaches that will optimally combine with native intrinsic repair processes (i.e., neuroplasticity) that can lead to improvement in function in spinal cord injury and other neurological disorders. To accomplish this we are investigating mechanisms associated with neuronal outgrowth, axon-glial interactions during axonal elongation and myelinogenesis, PNS and CNS demyelination and remyelination, glial responses to neuronal injury, axon-glial interactions, and neural tissue transplantation; immunology of neural tissue transplantation, magnetic resonance imaging of neural tissue; neurophysiological and behavioral correlates of spinal cord injury and repair, neural tissue culture and isolation of stem/progenitor cells from the adult CNS; ex vivo and in vivo gene delivery directed at neuronal rescue and regeneration in the injured nervous system; neural stem cell transplantation in CNS injury and repair. Recent Publications Cellular transplantation strategies for spinal cord injury and translational neurobiology. Special Issue on Cellular Repair and Neurological Disorders. Reier PJ (Guest Editors: O. Lindvall and A. Björklund) NeuroRx, 2004; 1: 424-451. Patterns of gene expression reveal a temporally orchestrated wound healing response in the injured spinal cord. Velardo MJ, Burger C, Williams PR, Baker HV, Lopez MC, Mareci TH, White TE, Muzyczka N, Reier PJ. J Neurosci. 2004 Sep 29;24(39):8562-76. Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Burger C, Gorbatyuk OS, Velardo MJ, Peden CS, Williams P, Zolotukhin S, Reier PJ, Mandel RJ, Muzyczka N. Mol Ther. 2004 Aug;10(2):302-17. Respiratory motor recovery after unilateral spinal cord injury: eliminating crossed phrenic activity decreases tidal volume and increases contralateral respiratory motor output. Golder FJ, Fuller DD, Davenport PW, Johnson RD, Reier PJ, Bolser DC. J Neurosci. 2003 Mar 15;23(6):2494-501.